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BSBM-03 A NOVEL COMBINED IMMUNOTHERAPY TO IMPROVE THERAPEUTIC RESPONSES IN SYMPTOMATIC BRAIN METASTASIS BASED ON TARGETING A SUBPOPULATION OF IMMUNOSUPPRESSIVE ASTROCYTES
The diagnosis of brain metastasis involves high morbidity and mortality. Recently, immune checkpoint blockade antibodies (ICB) have shown clinical benefits mainly when applied to asymptomatic brain metastasis patients. However, variability is broad and responses to this therapy drop considerably whe...
Autores principales: | Priego, Neibla, de Pablos-Aragoneses, Ana, Perea-García, María, Álvaro-Espinosa, Laura, Hernández-Oliver, Carolina, Martínez-Saez, Elena, Pérez-Núñez, Ángel, Hernández-Laín, Aurelio, Sanz-Pamplona, Rebeca, Schmitz, Marc, Crocker, Stephen J, Serrano, Diego, Calvo, Alfonso, Palazón, Asís, Valiente, Manuel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402391/ http://dx.doi.org/10.1093/noajnl/vdad070.001 |
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