BSBM-19 CROSS-PRESENTATION BY TUMOR-ASSOCIATED MACROPHAGES MEDIATES THE TRANSITION FROM PROGENITOR TO TERMINAL T CELL EXHAUSTION IN PRIMARY AND METASTATIC BRAIN TUMORS

Glioblastoma (GBM) and brain metastases remain largely resistant to immunotherapeutic intervention. T cell exhaustion, a differentiation state characterized by loss of function and persistence, contributes to this resistance. Two exhaustion subsets, progenitor (Tex_prog) and terminal (Tex_term), hav...

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Detalles Bibliográficos
Autores principales: Polania, Jessica Waibl, Hoyt-Miggelbrink, Alexandra, Tomaszweski, William, Wachsmuth, Luke, Lorrey, Selena, Fecci, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Basic Science of Brain Metastases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402396/
http://dx.doi.org/10.1093/noajnl/vdad070.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402396/
http://dx.doi.org/10.1093/noajnl/vdad070.015

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