Fragment-based design, synthesis and biological evaluation of theophylline derivatives as ATAD2 inhibitors in BT-549 cells

ATPase family AAA domain-containing protein 2 (ATAD2) has been emerging as a hot anti-cancer drugable target due to its oncogenic epigenetic modification closely associated with cancer cells proliferation, apoptosis, migration and drug resistance. In this study, we design a series of theophylline de...

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Detalles Bibliográficos
Autores principales: Yao, Dahong, You, Jieshu, Yang, Xuetao, Zhang, Jin, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402865/
https://www.ncbi.nlm.nih.gov/pubmed/37533352
http://dx.doi.org/10.1080/14756366.2023.2242601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402865/
https://www.ncbi.nlm.nih.gov/pubmed/37533352
http://dx.doi.org/10.1080/14756366.2023.2242601

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