Constitutive Turbodomains enhance expansion and antitumor activity of allogeneic BCMA CAR T cells in preclinical models

The magnitude of CAR T cell expansion has been associated with clinical efficacy. Although cytokines can augment CAR T cell proliferation, systemically administered cytokines can result in toxicities. To gain the benefits of cytokine signaling while mitigating toxicities, we designed constitutively...

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Detalles Bibliográficos
Autores principales: Lin, Regina J., Sutton, Janette, Bentley, Trevor, Vargas-Inchaustegui, Diego A., Nguyen, Duy, Cheng, Hsin-Yuan, Yoon, Hayung, Van Blarcom, Thomas J., Sasu, Barbra J., Panowski, Siler H., Sommer, Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403208/
https://www.ncbi.nlm.nih.gov/pubmed/37540748
http://dx.doi.org/10.1126/sciadv.adg8694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403208/
https://www.ncbi.nlm.nih.gov/pubmed/37540748
http://dx.doi.org/10.1126/sciadv.adg8694

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