Deploying synthetic coevolution and machine learning to engineer protein-protein interactions

Fine-tuning of protein-protein interactions occurs naturally through coevolution, but this process is difficult to recapitulate in the laboratory. We describe a synthetic platform for protein-protein coevolution that can isolate matched pairs of interacting muteins from complex libraries. This large...

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Detalles Bibliográficos
Autores principales: Yang, Aerin, Jude, Kevin M., Lai, Ben, Minot, Mason, Kocyla, Anna M., Glassman, Caleb R., Nishimiya, Daisuke, Kim, Yoon Seok, Reddy, Sai T., Khan, Aly A., Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403280/
https://www.ncbi.nlm.nih.gov/pubmed/37499032
http://dx.doi.org/10.1126/science.adh1720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403280/
https://www.ncbi.nlm.nih.gov/pubmed/37499032
http://dx.doi.org/10.1126/science.adh1720

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