In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

Intrinsic or added immune activating molecules are key for most vaccines to provide desired immunity profiles but may increase systemic reactogenicity. Regulatory agencies require rabbit pyrogen testing (RPT) for demonstration of vaccine reactogenicity. Recently, the monocyte activation test (MAT) g...

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Detalles Bibliográficos
Autores principales: Molenaar-de Backer, Marijke W. A., Doodeman, Paulien, Rezai, Fereshte, Verhagen, Lisa M., van der Ark, Arno, Plagmeijer, Els M., Metz, Bernard, van Vlies, Naomi, Ophorst, Olga, Raeven, René H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403550/
https://www.ncbi.nlm.nih.gov/pubmed/37542099
http://dx.doi.org/10.1038/s41598-023-39908-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403550/
https://www.ncbi.nlm.nih.gov/pubmed/37542099
http://dx.doi.org/10.1038/s41598-023-39908-7

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