Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

Pancreatic cancer is a highly aggressive cancer, and is primarily treated with gemcitabine, with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in lifespan and diverse diseases, such as cancer, diabetes, inflammation and neurodegenerative diseases. Considering the r...

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Detalles Bibliográficos
Autores principales: Song, Nannan, Guan, Xian, Zhang, Siqi, Wang, Yanqing, Wang, Xuekai, Lu, Zhongxia, Chong, Daochen, Wang, Jennifer Yiyang, Yu, Rilei, Yu, Wengong, Jiang, Tao, Gu, Yuchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
https://www.ncbi.nlm.nih.gov/pubmed/37542062
http://dx.doi.org/10.1038/s41419-023-06018-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
https://www.ncbi.nlm.nih.gov/pubmed/37542062
http://dx.doi.org/10.1038/s41419-023-06018-1

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