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Small EV in plasma of triple negative breast cancer patients induce intrinsic apoptosis in activated T cells
Small extracellular vesicles (sEV) in TNBC patients’ plasma promote T cell dysfunction and tumor progression. Here we show that tumor cell-derived exosomes (TEX) carrying surface PDL-1, PD-1, Fas, FasL, TRAIL, CTLA-4 and TGF-β1 induce apoptosis of CD8(+)T and CD4(+)T cells but spare B and NK cells....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403597/ https://www.ncbi.nlm.nih.gov/pubmed/37542121 http://dx.doi.org/10.1038/s42003-023-05169-3 |