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FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells
BACKGROUND: The FACT complex is a conserved histone chaperone with critical roles in transcription and histone deposition. FACT is essential in pluripotent and cancer cells, but otherwise dispensable for most mammalian cell types. FACT deletion or inhibition can block induction of pluripotent stem c...
Autores principales: | Klein, David C., Lardo, Santana M., McCannell, Kurtis N., Hainer, Sarah J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403911/ https://www.ncbi.nlm.nih.gov/pubmed/37542287 http://dx.doi.org/10.1186/s12915-023-01669-0 |
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