Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates

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Immunoglobulin G (IgG) antibodies coordinate immune effector responses by interacting with effector cells via fragment crystallizable γ (Fcγ) receptors. The IgG Fc domain directs effector responses through subclass and glycosylation variation. Although each Fc variant has been extensively characteri...

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Detalles Bibliográficos
Autores principales: Tan, Zhixin Cyrillus, Lux, Anja, Biburger, Markus, Varghese, Prabha, Lees, Stephen, Nimmerjahn, Falk, Meyer, Aaron S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404157/
https://www.ncbi.nlm.nih.gov/pubmed/37421619
http://dx.doi.org/10.1016/j.celrep.2023.112734
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