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Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data
Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a binary classification of chemical entities. For more than a decade, there has been a discussion about the need for a paradigm shift in this regard. Here, we review current opportunities, challenges and perspe...
Autores principales: | Menz, Jakob, Götz, Mario E., Gündel, Ulrike, Gürtler, Rainer, Herrmann, Kristin, Hessel-Pras, Stefanie, Kneuer, Carsten, Kolrep, Franziska, Nitzsche, Dana, Pabel, Ulrike, Sachse, Benjamin, Schmeisser, Sebastian, Schumacher, David M., Schwerdtle, Tanja, Tralau, Tewes, Zellmer, Sebastian, Schäfer, Bernd |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404208/ https://www.ncbi.nlm.nih.gov/pubmed/37402810 http://dx.doi.org/10.1007/s00204-023-03553-w |
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