Accelerated Apoptosis and Down-Regulated FMRP in Human Neuroblastoma Cells with CRISPR/Cas9 Genome Editing

BACKGROUND: Fragile X syndrome (FXS) is a genetic disease with intellectual disabilities. FXS is often caused by the CGG-repeat expansion mutation in the FMR1 gene with suppressed FMR1 transcription and decreased protein levels in the brain of the patients. The RNA-guided CRISPR/Cas9 system is a pro...

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Detalles Bibliográficos
Autores principales: Zhang, Rong, Xu, Huifen, Lu, Jin, Chen, Ying, Zhang, Yahui, Xiao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404333/
https://www.ncbi.nlm.nih.gov/pubmed/37551173
http://dx.doi.org/10.18502/ijph.v52i4.12438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404333/
https://www.ncbi.nlm.nih.gov/pubmed/37551173
http://dx.doi.org/10.18502/ijph.v52i4.12438

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