Evaluating the Frequencies of CNOT3, GRIA1, NFATC2, and PNPLA3 Variant Alleles and Their Association with L-Asparaginase Hypersensitivity in Pediatric Acute Lymphoblastic Leukemia in Addis Ababa, Ethiopia

INTRODUCTION: L-asparaginase is a vital component for the treatment of childhood acute lymphoblastic leukemia (ALL); however, hypersensitivity reactions and hepatotoxicity hinder its anti-neoplastic efficacy. Previous reports indicated that genetic variants in CNOT3, GRIA1, and NFATC2 genes might be...

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Detalles Bibliográficos
Autores principales: Ali, Awol Mekonnen, Adam, Haileyesus, Hailu, Daniel, Howe, Rawleigh, Abula, Teferra, Coenen, Marieke J H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404408/
https://www.ncbi.nlm.nih.gov/pubmed/37551203
http://dx.doi.org/10.2147/TACG.S404695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404408/
https://www.ncbi.nlm.nih.gov/pubmed/37551203
http://dx.doi.org/10.2147/TACG.S404695

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