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HIB/SPOP inhibits Ci/Gli-mediated tumorigenesis by modulating the RNA Polymerase II components stabilities
Hedgehog (Hh) signaling mediated by transcription factor Ci/Gli plays a vital role in embryonic development and adult tissue homeostasis in invertebrates and vertebrates, whose dysregulation leads to many human disorders, including cancer. However, till now, cofactors of Ci/Gli which can affect tumo...
Autores principales: | Gao, Yuxue, Shan, Zhaoliang, Jian, Chunhua, Wang, Ying, Yao, Xia, Li, Shengnan, Ti, Xiuxiu, Zhao, Guochun, Liu, Chen, Zhang, Qing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404538/ https://www.ncbi.nlm.nih.gov/pubmed/37554435 http://dx.doi.org/10.1016/j.isci.2023.107334 |
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