Aβ43 levels determine the onset of pathological amyloid deposition

About 2% of Alzheimer’s disease (AD) cases have early onset (FAD) and are caused by mutations in either Presenilins (PSEN1/2) or amyloid-β precursor protein (APP). PSEN1/2 catalyze production of Aβ peptides of different length from APP. Aβ peptides are the major components of amyloid plaques, a path...

Descripción completa

Detalles Bibliográficos
Autores principales: Tambini, Marc D., Yin, Tao, Yesiltepe, Metin, Breuillaud, Lionel, Zehntner, Simone P., d'Abramo, Cristina, Giliberto, Luca, D'Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404620/
https://www.ncbi.nlm.nih.gov/pubmed/37257821
http://dx.doi.org/10.1016/j.jbc.2023.104868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404620/
https://www.ncbi.nlm.nih.gov/pubmed/37257821
http://dx.doi.org/10.1016/j.jbc.2023.104868

Ejemplares similares