Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect

Withdrawal from chronic opioid use often causes hypodopaminergic states and negative affect, which may drive relapse. Direct-pathway medium spiny neurons (dMSNs) in the striatal patch compartment contain μ-opioid receptors (MORs). It remains unclear how chronic opioid exposure and withdrawal impact...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Xie, Xueyi, Zhuang, Xiaowen, Huang, Yufei, Tan, Tao, Gangal, Himanshu, Huang, Zhenbo, Purvines, William, Wang, Xuehua, Stefanov, Alexander, Chen, Ruifeng, Rodriggs, Lucas, Chaiprasert, Anita, Yu, Emily, Vierkant, Valerie, Hook, Michelle, Huang, Yun, Darcq, Emmanuel, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404641/
https://www.ncbi.nlm.nih.gov/pubmed/36796365
http://dx.doi.org/10.1016/j.celrep.2023.112089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404641/
https://www.ncbi.nlm.nih.gov/pubmed/36796365
http://dx.doi.org/10.1016/j.celrep.2023.112089

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