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A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding

Collagen superfamily of proteins is a major component of the extracellular matrix. Defects in collagens underlie the cause of nearly 40 human genetic diseases in millions of people worldwide. Pathogenesis typically involves genetic alterations of the triple helix, a hallmark structural feature that...

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Detalles Bibliográficos
Autores principales: Boudko, Sergei P., Konopka, Elizabeth H., Kim, Woojin, Taga, Yuki, Mizuno, Kazunori, Springer, Timothy A., Hudson, Billy G., Moy, Terence I., Lin, Fu-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404678/
https://www.ncbi.nlm.nih.gov/pubmed/37302550
http://dx.doi.org/10.1016/j.jbc.2023.104901