Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114

α-synuclein (αS) is an abundant, neuronal protein that assembles into fibrillar pathological inclusions in a spectrum of neurodegenerative diseases that include Lewy body diseases (LBD) and Multiple System Atrophy (MSA). The cellular and regional distributions of pathological inclusions vary widely...

Descripción completa

Detalles Bibliográficos
Autores principales: Quintin, Stephan, Lloyd, Grace M., Paterno, Giavanna, Xia, Yuxing, Sorrentino, Zachary, Bell, Brach M., Gorion, Kimberly-Marie, Lee, Edward B., Prokop, Stefan, Giasson, Benoit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404685/
https://www.ncbi.nlm.nih.gov/pubmed/37307916
http://dx.doi.org/10.1016/j.jbc.2023.104912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404685/
https://www.ncbi.nlm.nih.gov/pubmed/37307916
http://dx.doi.org/10.1016/j.jbc.2023.104912

Ejemplares similares