Platelet ITGA2B inhibits caspase-8 and Rip3/Mlkl-dependent platelet death though PTPN6 during sepsis

Platelets play an important role in the pathogenesis of sepsis and platelet transfusion is a therapeutic option for sepsis patients, although the exact mechanisms have not been elucidated so far. ITGA2B encodes the αIIb protein in platelets, and its upregulation in sepsis is associated with increase...

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Detalles Bibliográficos
Autores principales: Jiang, Jiang, Li, Wei, Zhou, Lu, Liu, Dengping, Wang, Yuanyuan, An, Jianzhong, Qiao, Shigang, Xie, Zhanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404729/
https://www.ncbi.nlm.nih.gov/pubmed/37554440
http://dx.doi.org/10.1016/j.isci.2023.107414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404729/
https://www.ncbi.nlm.nih.gov/pubmed/37554440
http://dx.doi.org/10.1016/j.isci.2023.107414

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