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Evolution and optimization of clinical trial endpoints and design in pulmonary arterial hypertension

Selection of endpoints for clinical trials in pulmonary arterial hypertension (PAH) is challenging because of the small numbers of patients and the changing expectations of patients, clinicians, and regulators in this evolving therapy area. The most commonly used primary endpoint in PAH trials has b...

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Detalles Bibliográficos
Autores principales: Caccamo, Marco, Harrell, Frank E., Hemnes, Anna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405062/
https://www.ncbi.nlm.nih.gov/pubmed/37554146
http://dx.doi.org/10.1002/pul2.12271