LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR‐activation screens in ferroptosis hypersensitive cells, we identify the selenop...

Descripción completa

Detalles Bibliográficos
Autores principales: Alborzinia, Hamed, Chen, Zhiyi, Yildiz, Umut, Freitas, Florencio Porto, Vogel, Felix C E, Varga, Julianna Patricia, Batani, Jasmin, Bartenhagen, Christoph, Schmitz, Werner, Büchel, Gabriele, Michalke, Bernhard, Zheng, Jashuo, Meierjohann, Svenja, Girardi, Enrico, Espinet, Elisa, Flórez, Andrés F, dos Santos, Ancely Ferreira, Aroua, Nesrine, Cheytan, Tasneem, Haenlin, Julie, Schlicker, Lisa, Xavier da Silva, Thamara N, Przybylla, Adriana, Zeisberger, Petra, Superti‐Furga, Giulio, Eilers, Martin, Conrad, Marcus, Fabiano, Marietta, Schweizer, Ulrich, Fischer, Matthias, Schulze, Almut, Trumpp, Andreas, Friedmann Angeli, José Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405063/
https://www.ncbi.nlm.nih.gov/pubmed/37435859
http://dx.doi.org/10.15252/emmm.202318014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405063/
https://www.ncbi.nlm.nih.gov/pubmed/37435859
http://dx.doi.org/10.15252/emmm.202318014

Ejemplares similares