Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF

Increased fetal hemoglobin (HbF) levels reduce the symptoms of sickle cell disease (SCD) and increase the lifespan of patients. Because curative strategies for bone marrow transplantation and gene therapy technologies remain unavailable to a large number of patients, the development of a safe and ef...

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Detalles Bibliográficos
Autores principales: Ibanez, Vinzon, Vaitkus, Kestis, Zhang, Xu, Ramasamy, Jagadeesh, Rivers, Angela E., Saunthararajah, Yogen, Molokie, Robert, Lavelle, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405201/
https://www.ncbi.nlm.nih.gov/pubmed/36884303
http://dx.doi.org/10.1182/bloodadvances.2022009558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405201/
https://www.ncbi.nlm.nih.gov/pubmed/36884303
http://dx.doi.org/10.1182/bloodadvances.2022009558

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