Self-Assembly of Insulin-Derived Chimeric Peptides into Two-Component Amyloid Fibrils: The Role of Coulombic Interactions

[Image: see text] Canonical amyloid fibrils are composed of covalently identical polypeptide chains. Here, we employ kinetic assays, atomic force microscopy, infrared spectroscopy, circular dichroism, and molecular dynamics simulations to study fibrillization patterns of two chimeric peptides, ACC(1...

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Detalles Bibliográficos
Autores principales: Fortunka, Mateusz, Dec, Robert, Puławski, Wojciech, Guza, Marcin, Dzwolak, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405213/
https://www.ncbi.nlm.nih.gov/pubmed/37492019
http://dx.doi.org/10.1021/acs.jpcb.3c00976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405213/
https://www.ncbi.nlm.nih.gov/pubmed/37492019
http://dx.doi.org/10.1021/acs.jpcb.3c00976

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