The SWI/SNF complex member SMARCB1 supports lineage fidelity in kidney cancer

Lineage switching can induce therapy resistance in cancer. Yet, how lineage fidelity is maintained and how it can be lost remain poorly understood. Here, we have used CRISPR-Cas9-based genetic screening to demonstrate that loss of SMARCB1, a member of the SWI/SNF chromatin remodeling complex, can co...

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Detalles Bibliográficos
Autores principales: Wesolowski, Ludovic, Ge, Jianfeng, Castillon, Leticia, Sesia, Debora, Dyas, Anna, Hirosue, Shoko, Caraffini, Veronica, Warren, Anne Y., Rodrigues, Paulo, Ciriello, Giovanni, Patel, Saroor A., Vanharanta, Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405256/
https://www.ncbi.nlm.nih.gov/pubmed/37554444
http://dx.doi.org/10.1016/j.isci.2023.107360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405256/
https://www.ncbi.nlm.nih.gov/pubmed/37554444
http://dx.doi.org/10.1016/j.isci.2023.107360

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