Click-to-Release: Cleavable Radioimmunoimaging with [(89)Zr]Zr-DFO-Trans-Cyclooctene-Trastuzumab Increases Tumor-to-Blood Ratio

One of the main challenges of PET imaging with (89)Zr-labeled monoclonal antibodies (mAbs) remains the long blood circulation of the radiolabeled mAbs, leading to high background signals, decreasing image quality. To overcome this limitation, here we report the use of a bioorthogonal linker cleavage...

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Detalles Bibliográficos
Autores principales: Vlastara, Maria, Rossin, Raffaella, Hoeben, Freek J.M., de Roode, Kim E., Boswinkel, Milou, Kleijn, Laurens H.J., Nagarajah, James, Rijpkema, Mark, Robillard, Marc S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405837/
https://www.ncbi.nlm.nih.gov/pubmed/37554267
http://dx.doi.org/10.7150/thno.84865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405837/
https://www.ncbi.nlm.nih.gov/pubmed/37554267
http://dx.doi.org/10.7150/thno.84865

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