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Fusogenic structural changes in arenavirus glycoproteins are associated with viroporin activity

Many enveloped viruses enter host cells by fusing with acidic endosomes. The fusion activity of multiple viral envelope glycoproteins does not generally affect viral membrane permeability. However, fusion induced by the Lassa virus (LASV) glycoprotein complex (GPc) is always preceded by an increase...

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Detalles Bibliográficos
Autores principales: Zhang, You, York, Joanne, Brindley, Melinda A., Nunberg, Jack H., Melikyan, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406333/
https://www.ncbi.nlm.nih.gov/pubmed/37494374
http://dx.doi.org/10.1371/journal.ppat.1011217