TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination

Atherosclerosis is a chronic inflammatory disease and the main pathology behind most cardiovascular diseases and the overactivation of macrophages initiates the development of atherosclerosis. However, the specific functions of oxidized low-density lipoprotein (ox-LDL) in macrophages remain elusive....

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Detalles Bibliográficos
Autores principales: Zhu, Chao, Chen, Wei, Cui, Haiming, Huang, Zhigang, Ding, Ru, Li, Na, Wang, Qinqin, Wu, Feng, Zhao, Yanmin, Cong, Xiaoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406714/
https://www.ncbi.nlm.nih.gov/pubmed/36229750
http://dx.doi.org/10.1007/s10565-022-09768-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406714/
https://www.ncbi.nlm.nih.gov/pubmed/36229750
http://dx.doi.org/10.1007/s10565-022-09768-4

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