Cargando…

TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination

Atherosclerosis is a chronic inflammatory disease and the main pathology behind most cardiovascular diseases and the overactivation of macrophages initiates the development of atherosclerosis. However, the specific functions of oxidized low-density lipoprotein (ox-LDL) in macrophages remain elusive....

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Chao, Chen, Wei, Cui, Haiming, Huang, Zhigang, Ding, Ru, Li, Na, Wang, Qinqin, Wu, Feng, Zhao, Yanmin, Cong, Xiaoliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406714/ https://www.ncbi.nlm.nih.gov/pubmed/36229750 http://dx.doi.org/10.1007/s10565-022-09768-4

Ejemplares similares

Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage
por: Zhang, Heng, et al.
Publicado: (2015)

Oncostatin M promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the NF-κB pathway in THP-1 macrophages and promotes the progression of atherosclerosis
por: Liu, Cheng, et al.
Publicado: (2022)

Ox-LDL Induces Dysfunction of Endothelial Progenitor Cells via Activation of NF-κB
por: Ji, Kang-ting, et al.
Publicado: (2015)

Genome-wide profiling to analyze the effects of Ox-LDL induced THP-1 macrophage-derived foam cells on gene expression
por: Hu, Yan-Wei, et al.
Publicado: (2014)

Dan-Lou Prescription Inhibits Foam Cell Formation Induced by ox-LDL via the TLR4/NF-κB and PPARγ Signaling Pathways
por: Gao, Li-Na, et al.
Publicado: (2018)

Modified Yuejuwan Inhibited Cholesterol Accumulation and Inflammation in THP-1 Macrophage-Derived Foam Cells by Inhibiting the Activity of the TRIM37/TRAF2/NF-κB Pathway
por: Gui, Mingtai, et al.
Publicado: (2022)

K63 ubiquitin chains target NLRP3 inflammasome for autophagic degradation in ox-LDL-stimulated THP-1 macrophages
por: Zhou, Zhenfeng, et al.
Publicado: (2020)

FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells
por: Li, En, et al.
Publicado: (2015)

Metformin suppresses foam cell formation, inflammation and ferroptosis via the AMPK/ERK signaling pathway in ox‑LDL‑induced THP‑1 monocytes
por: Zhao, Yihan, et al.
Publicado: (2022)

Geniposide suppressed OX-LDL-induced osteoblast apoptosis by regulating the NRF2/NF-κB signaling pathway
por: Xiao, Yaosheng, et al.
Publicado: (2023)

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation
por: Wang, Haoran, et al.
Publicado: (2020)

Ginsenoside Compound K Attenuates Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation via Autophagy Induction and Modulating NF-κB, p38, and JNK MAPK Signaling
por: Lu, Shan, et al.
Publicado: (2020)

TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα
por: Ji, Jianxiong, et al.
Publicado: (2020)

Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-κB and MAPK Pathways in Macrophages
por: Cao, Jiatian, et al.
Publicado: (2017)

Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages
por: Yin, Mengzhuo, et al.
Publicado: (2021)

Curcumin affects ox-LDL-induced IL-6, TNF-α, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-κB/miR33a signaling pathway
por: Zhong, Yi, et al.
Publicado: (2020)

Niacin Reverses Migratory Macrophage Foam Cell Arrest Mediated by oxLDL In Vitro
por: Huang, Hua, et al.
Publicado: (2014)

Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation
por: Schwarz, Anja, et al.
Publicado: (2017)

The Ubiquitination of NF-κB Subunits in the Control of Transcription
por: Collins, Patricia E., et al.
Publicado: (2016)

The Many Roles of Ubiquitin in NF-κB Signaling
por: Courtois, Gilles, et al.
Publicado: (2018)

LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma
por: Wang, Heran, et al.
Publicado: (2019)

Global Metabolomics Reveals the Metabolic Dysfunction in Ox-LDL Induced Macrophage-Derived Foam Cells
por: Xu, Wenjuan, et al.
Publicado: (2017)

Protective effects of mitochondrial fission inhibition on ox-LDL induced VSMC foaming via metabolic reprogramming
por: Fang, Yijin, et al.
Publicado: (2022)

Silencing of Transient Receptor Potential Channel 4 Alleviates oxLDL-induced Angiogenesis in Human Coronary Artery Endothelial Cells by Inhibition of VEGF and NF-κB
por: Qin, Wen, et al.
Publicado: (2016)

Resveratrol Inhibits MMP3 and MMP9 Expression and Secretion by Suppressing TLR4/NF-κB/STAT3 Activation in Ox-LDL-Treated HUVECs
por: Zhang, Ming, et al.
Publicado: (2019)

Novel H(2)S donor proglumide-ADT-OH protects HUVECs from ox-LDL-induced injury through NF-κB and JAK/SATA pathway
por: Ou, Xuelan, et al.
Publicado: (2021)

TRIM27 interacts with Iκbα to promote the growth of human renal cancer cells through regulating the NF-κB pathway
por: Xiao, Chengwu, et al.
Publicado: (2021)

Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis
por: Liu, Jiaru, et al.
Publicado: (2021)

Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity
por: Aillet, Fabienne, et al.
Publicado: (2012)

Augmented Osteogenic Responses in Human Aortic Valve Cells Exposed to oxLDL and TLR4 Agonist: A Mechanistic Role of Notch1 and NF-κB Interaction
por: Zeng, Qingchun, et al.
Publicado: (2014)

OxLDL/β2GPI/anti-β2GPI Ab complex induces inflammatory activation via the TLR4/NF-κB pathway in HUVECs
por: Zhang, Guiting, et al.
Publicado: (2021)

The Role of Ubiquitination in NF-κB Signaling during Virus Infection
por: Song, Kun, et al.
Publicado: (2021)

TRIM31 promotes glioma proliferation and invasion through activating NF-κB pathway
por: Zhou, Li, et al.
Publicado: (2019)

TRIM14 promotes endothelial activation via activating NF-κB signaling pathway
por: Huang, Xuan, et al.
Publicado: (2019)

Zhilong Huoxue Tongyu Capsule Alleviated the Pyroptosis of Vascular Endothelial Cells Induced by ox-LDL through miR-30b-5p/NLRP3
por: Liu, Mengnan, et al.
Publicado: (2022)

Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα
por: Hu, Xiaolei, et al.
Publicado: (2020)

LOX-1, OxLDL, and Atherosclerosis
por: Pirillo, Angela, et al.
Publicado: (2013)

Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL
por: Kimmel, Danielle W., et al.
Publicado: (2017)

TRIM59 attenuates ox-LDL-induced endothelial cell inflammation, apoptosis, and monocyte adhesion through AnxA2
por: Zeng, Qilin, et al.
Publicado: (2023)

LOX-1 Activation by oxLDL Induces AR and AR-V7 Expression via NF-κB and STAT3 Signaling Pathways Reducing Enzalutamide Cytotoxic Effects
por: Duprat, Felix, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ifi8463sqclrh6fgd4hjlgpo05