Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

The mitochondrial permeability transition (mPT) describes a Ca(2+)-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It is mediated by a non-selective channel, the mitochondrial permeability...

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Detalles Bibliográficos
Autores principales: Bernardi, Paolo, Gerle, Christoph, Halestrap, Andrew P., Jonas, Elizabeth A., Karch, Jason, Mnatsakanyan, Nelli, Pavlov, Evgeny, Sheu, Shey-Shing, Soukas, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406888/
https://www.ncbi.nlm.nih.gov/pubmed/37460667
http://dx.doi.org/10.1038/s41418-023-01187-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406888/
https://www.ncbi.nlm.nih.gov/pubmed/37460667
http://dx.doi.org/10.1038/s41418-023-01187-0

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