Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism

The lasso peptide MS-271 is a ribosomally synthesized and post-translationally modified peptide (RiPP) consisting of 21 amino acids with D-tryptophan at the C-terminus, and is derived from the precursor peptide MslA. MslH, encoded in the MS-271 biosynthetic gene cluster (msl), catalyzes the epimeriz...

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Detalles Bibliográficos
Autores principales: Nakashima, Yu, Kawakami, Atsushi, Ogasawara, Yasushi, Maeki, Masatoshi, Tokeshi, Manabu, Dairi, Tohru, Morita, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406935/
https://www.ncbi.nlm.nih.gov/pubmed/37550286
http://dx.doi.org/10.1038/s41467-023-40232-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406935/
https://www.ncbi.nlm.nih.gov/pubmed/37550286
http://dx.doi.org/10.1038/s41467-023-40232-x

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