Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection

BACKGROUND: Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/severe COVID-19, led us to determine, in an exploratory observa...

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Detalles Bibliográficos
Autores principales: Guo, Lihui, Appelman, Brent, Mooij-Kalverda, Kirsten, Houtkooper, Riekelt H., van Weeghel, Michel, Vaz, Frédéric M., Dijkhuis, Annemiek, Dekker, Tamara, Smids, Barbara S., Duitman, Jan Willem, Bugiani, Marianna, Brinkman, Paul, Sikkens, Jonne J., Lavell, H.A. Ayesha, Wüst, Rob C.I., van Vugt, Michèle, Lutter, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406961/
https://www.ncbi.nlm.nih.gov/pubmed/37506544
http://dx.doi.org/10.1016/j.ebiom.2023.104729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406961/
https://www.ncbi.nlm.nih.gov/pubmed/37506544
http://dx.doi.org/10.1016/j.ebiom.2023.104729

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