Enrichment analysis of phenotypic data for drug repurposing in rare diseases

Drug-induced Behavioral Signature Analysis (DBSA), is a machine learning (ML) method for in silico screening of compounds, inspired by analytical methods quantifying gene enrichment in genomic analyses. When applied to behavioral data it can identify drugs that can potentially reverse in vivo behavi...

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Detalles Bibliográficos
Autores principales: Ambesi-Impiombato, Alberto, Cox, Kimberly, Ramboz, Sylvie, Brunner, Daniela, Bansal, Mukesh, Leahy, Emer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407094/
https://www.ncbi.nlm.nih.gov/pubmed/37560472
http://dx.doi.org/10.3389/fphar.2023.1128562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407094/
https://www.ncbi.nlm.nih.gov/pubmed/37560472
http://dx.doi.org/10.3389/fphar.2023.1128562

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