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The cytoplasmic fraction of the histone lysine methyltransferase Setdb1 is essential for embryonic stem cells
The major lysine methyltransferase (KMT) Setdb1 is essential for self-renewal and viability of mouse embryonic stem cells (mESCs). Setdb1 was primarily known to methylate the lysine 9 of histone 3 (H3K9) in the nucleus, where it regulates chromatin functions. However, Setdb1 is also massively locali...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407132/ https://www.ncbi.nlm.nih.gov/pubmed/37559904 http://dx.doi.org/10.1016/j.isci.2023.107386 |