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Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia

This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic opportunities to target leukaemia–niche interactions. The tumour microenvironment plays an integral role in conferring treatment resistance to leu...

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Detalles Bibliográficos
Autores principales: Parker, Jessica, Hockney, Sean, Blaschuk, Orest W., Pal, Deepali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407222/
https://www.ncbi.nlm.nih.gov/pubmed/37132370
http://dx.doi.org/10.1017/erm.2023.13
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author Parker, Jessica
Hockney, Sean
Blaschuk, Orest W.
Pal, Deepali
author_facet Parker, Jessica
Hockney, Sean
Blaschuk, Orest W.
Pal, Deepali
author_sort Parker, Jessica
collection PubMed
description This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic opportunities to target leukaemia–niche interactions. The tumour microenvironment plays an integral role in conferring treatment resistance to leukaemia cells, this poses as a key clinical challenge that hinders management of this disease. Here we focus on the role of the cell adhesion molecule N-cadherin (CDH2) within the malignant BM microenvironment and associated signalling pathways that may bear promise as therapeutic targets. Additionally, we discuss microenvironment-driven treatment resistance and relapse, and elaborate the role of CDH2-mediated cancer cell protection from chemotherapy. Finally, we review emerging therapeutic approaches that directly target CDH2-mediated adhesive interactions between the BM cells and leukaemia cells.
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spelling pubmed-104072222023-08-09 Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia Parker, Jessica Hockney, Sean Blaschuk, Orest W. Pal, Deepali Expert Rev Mol Med Review This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic opportunities to target leukaemia–niche interactions. The tumour microenvironment plays an integral role in conferring treatment resistance to leukaemia cells, this poses as a key clinical challenge that hinders management of this disease. Here we focus on the role of the cell adhesion molecule N-cadherin (CDH2) within the malignant BM microenvironment and associated signalling pathways that may bear promise as therapeutic targets. Additionally, we discuss microenvironment-driven treatment resistance and relapse, and elaborate the role of CDH2-mediated cancer cell protection from chemotherapy. Finally, we review emerging therapeutic approaches that directly target CDH2-mediated adhesive interactions between the BM cells and leukaemia cells. Cambridge University Press 2023-05-03 /pmc/articles/PMC10407222/ /pubmed/37132370 http://dx.doi.org/10.1017/erm.2023.13 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Review
Parker, Jessica
Hockney, Sean
Blaschuk, Orest W.
Pal, Deepali
Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia
title Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia
title_full Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia
title_fullStr Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia
title_full_unstemmed Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia
title_short Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia
title_sort targeting n-cadherin (cdh2) and the malignant bone marrow microenvironment in acute leukaemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407222/
https://www.ncbi.nlm.nih.gov/pubmed/37132370
http://dx.doi.org/10.1017/erm.2023.13
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