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Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
In utero exposure to maternal stress, anxiety, and depression has been associated with reduced cortical thickness (CT), and CT changes, in turn, to adverse neuropsychiatric outcomes. Here, we investigated global and regional (G/RCT) changes associated with fetal exposure to maternal psychological di...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407290/ https://www.ncbi.nlm.nih.gov/pubmed/37515833 http://dx.doi.org/10.1016/j.dcn.2023.101282 |
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author | De Asis-Cruz, Josepheen Kim, Jung-Hoon Krishnamurthy, Dhineshvikram Lopez, Catherine Kapse, Kushal Andescavage, Nickie Vezina, Gilbert Limperopoulos, Catherine |
author_facet | De Asis-Cruz, Josepheen Kim, Jung-Hoon Krishnamurthy, Dhineshvikram Lopez, Catherine Kapse, Kushal Andescavage, Nickie Vezina, Gilbert Limperopoulos, Catherine |
author_sort | De Asis-Cruz, Josepheen |
collection | PubMed |
description | In utero exposure to maternal stress, anxiety, and depression has been associated with reduced cortical thickness (CT), and CT changes, in turn, to adverse neuropsychiatric outcomes. Here, we investigated global and regional (G/RCT) changes associated with fetal exposure to maternal psychological distress in 265 brain MRI studies from 177 healthy fetuses of low-risk pregnant women. GCT was measured from cortical gray matter (CGM) voxels; RCT was estimated from 82 cortical regions. GCT and RCT in 87% of regions strongly correlated with GA. Fetal exposure was most strongly associated with RCT in the parahippocampal region, ventromedial prefrontal cortex, and supramarginal gyrus suggesting that cortical alterations commonly associated with prenatal exposure could emerge in-utero. However, we note that while regional fetal brain involvement conformed to patterns observed in newborns and children exposed to prenatal maternal psychological distress, the reported associations did not survive multiple comparisons correction. This could be because the effects are more subtle in this early developmental window or because majority of the pregnant women in our study did not experience high levels of maternal distress. It is our hope that the current findings will spur future hypothesis-driven studies that include a full spectrum of maternal mental health scores. |
format | Online Article Text |
id | pubmed-10407290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104072902023-08-09 Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress De Asis-Cruz, Josepheen Kim, Jung-Hoon Krishnamurthy, Dhineshvikram Lopez, Catherine Kapse, Kushal Andescavage, Nickie Vezina, Gilbert Limperopoulos, Catherine Dev Cogn Neurosci Original Research In utero exposure to maternal stress, anxiety, and depression has been associated with reduced cortical thickness (CT), and CT changes, in turn, to adverse neuropsychiatric outcomes. Here, we investigated global and regional (G/RCT) changes associated with fetal exposure to maternal psychological distress in 265 brain MRI studies from 177 healthy fetuses of low-risk pregnant women. GCT was measured from cortical gray matter (CGM) voxels; RCT was estimated from 82 cortical regions. GCT and RCT in 87% of regions strongly correlated with GA. Fetal exposure was most strongly associated with RCT in the parahippocampal region, ventromedial prefrontal cortex, and supramarginal gyrus suggesting that cortical alterations commonly associated with prenatal exposure could emerge in-utero. However, we note that while regional fetal brain involvement conformed to patterns observed in newborns and children exposed to prenatal maternal psychological distress, the reported associations did not survive multiple comparisons correction. This could be because the effects are more subtle in this early developmental window or because majority of the pregnant women in our study did not experience high levels of maternal distress. It is our hope that the current findings will spur future hypothesis-driven studies that include a full spectrum of maternal mental health scores. Elsevier 2023-07-20 /pmc/articles/PMC10407290/ /pubmed/37515833 http://dx.doi.org/10.1016/j.dcn.2023.101282 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research De Asis-Cruz, Josepheen Kim, Jung-Hoon Krishnamurthy, Dhineshvikram Lopez, Catherine Kapse, Kushal Andescavage, Nickie Vezina, Gilbert Limperopoulos, Catherine Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress |
title | Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress |
title_full | Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress |
title_fullStr | Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress |
title_full_unstemmed | Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress |
title_short | Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress |
title_sort | examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407290/ https://www.ncbi.nlm.nih.gov/pubmed/37515833 http://dx.doi.org/10.1016/j.dcn.2023.101282 |
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