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Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress

In utero exposure to maternal stress, anxiety, and depression has been associated with reduced cortical thickness (CT), and CT changes, in turn, to adverse neuropsychiatric outcomes. Here, we investigated global and regional (G/RCT) changes associated with fetal exposure to maternal psychological di...

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Autores principales: De Asis-Cruz, Josepheen, Kim, Jung-Hoon, Krishnamurthy, Dhineshvikram, Lopez, Catherine, Kapse, Kushal, Andescavage, Nickie, Vezina, Gilbert, Limperopoulos, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407290/
https://www.ncbi.nlm.nih.gov/pubmed/37515833
http://dx.doi.org/10.1016/j.dcn.2023.101282
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author De Asis-Cruz, Josepheen
Kim, Jung-Hoon
Krishnamurthy, Dhineshvikram
Lopez, Catherine
Kapse, Kushal
Andescavage, Nickie
Vezina, Gilbert
Limperopoulos, Catherine
author_facet De Asis-Cruz, Josepheen
Kim, Jung-Hoon
Krishnamurthy, Dhineshvikram
Lopez, Catherine
Kapse, Kushal
Andescavage, Nickie
Vezina, Gilbert
Limperopoulos, Catherine
author_sort De Asis-Cruz, Josepheen
collection PubMed
description In utero exposure to maternal stress, anxiety, and depression has been associated with reduced cortical thickness (CT), and CT changes, in turn, to adverse neuropsychiatric outcomes. Here, we investigated global and regional (G/RCT) changes associated with fetal exposure to maternal psychological distress in 265 brain MRI studies from 177 healthy fetuses of low-risk pregnant women. GCT was measured from cortical gray matter (CGM) voxels; RCT was estimated from 82 cortical regions. GCT and RCT in 87% of regions strongly correlated with GA. Fetal exposure was most strongly associated with RCT in the parahippocampal region, ventromedial prefrontal cortex, and supramarginal gyrus suggesting that cortical alterations commonly associated with prenatal exposure could emerge in-utero. However, we note that while regional fetal brain involvement conformed to patterns observed in newborns and children exposed to prenatal maternal psychological distress, the reported associations did not survive multiple comparisons correction. This could be because the effects are more subtle in this early developmental window or because majority of the pregnant women in our study did not experience high levels of maternal distress. It is our hope that the current findings will spur future hypothesis-driven studies that include a full spectrum of maternal mental health scores.
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spelling pubmed-104072902023-08-09 Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress De Asis-Cruz, Josepheen Kim, Jung-Hoon Krishnamurthy, Dhineshvikram Lopez, Catherine Kapse, Kushal Andescavage, Nickie Vezina, Gilbert Limperopoulos, Catherine Dev Cogn Neurosci Original Research In utero exposure to maternal stress, anxiety, and depression has been associated with reduced cortical thickness (CT), and CT changes, in turn, to adverse neuropsychiatric outcomes. Here, we investigated global and regional (G/RCT) changes associated with fetal exposure to maternal psychological distress in 265 brain MRI studies from 177 healthy fetuses of low-risk pregnant women. GCT was measured from cortical gray matter (CGM) voxels; RCT was estimated from 82 cortical regions. GCT and RCT in 87% of regions strongly correlated with GA. Fetal exposure was most strongly associated with RCT in the parahippocampal region, ventromedial prefrontal cortex, and supramarginal gyrus suggesting that cortical alterations commonly associated with prenatal exposure could emerge in-utero. However, we note that while regional fetal brain involvement conformed to patterns observed in newborns and children exposed to prenatal maternal psychological distress, the reported associations did not survive multiple comparisons correction. This could be because the effects are more subtle in this early developmental window or because majority of the pregnant women in our study did not experience high levels of maternal distress. It is our hope that the current findings will spur future hypothesis-driven studies that include a full spectrum of maternal mental health scores. Elsevier 2023-07-20 /pmc/articles/PMC10407290/ /pubmed/37515833 http://dx.doi.org/10.1016/j.dcn.2023.101282 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
De Asis-Cruz, Josepheen
Kim, Jung-Hoon
Krishnamurthy, Dhineshvikram
Lopez, Catherine
Kapse, Kushal
Andescavage, Nickie
Vezina, Gilbert
Limperopoulos, Catherine
Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
title Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
title_full Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
title_fullStr Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
title_full_unstemmed Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
title_short Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
title_sort examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407290/
https://www.ncbi.nlm.nih.gov/pubmed/37515833
http://dx.doi.org/10.1016/j.dcn.2023.101282
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