T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis

Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell intrinsic STAT1 signaling is required to curb inflammation during acute infection with Toxoplasma gondii. Specifically, we report that mice lacki...

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Detalles Bibliográficos
Autores principales: Schultz, Aaron B., Kugler, David G., Nivelo, Luis, Vitari, Nicolas, Doyle, Laura P., Ristin, Svetlana, Hennighausen, Lothar, O’Shea, John J., Jankovic, Dragana, Villarino, Alejandro V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407301/
https://www.ncbi.nlm.nih.gov/pubmed/37559725
http://dx.doi.org/10.3389/fimmu.2023.1212190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407301/
https://www.ncbi.nlm.nih.gov/pubmed/37559725
http://dx.doi.org/10.3389/fimmu.2023.1212190

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