Cargando…

Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system

BACKGROUND: The genetic code does not fully explain individual variability and inheritance of susceptibility to endocrine conditions, suggesting the contribution of epigenetic factors acting across generations. METHODS: We used a mouse model of developmental thyrotoxicosis (Dio3-/- mouse) to analyze...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martinez, Maria Elena, Wu, Zhaofei, Hernandez, Arturo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407661/ https://www.ncbi.nlm.nih.gov/pubmed/37560296 http://dx.doi.org/10.3389/fendo.2023.1210414

Ejemplares similares

Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity
por: Šket, Robert, et al.
Publicado: (2022)

Melanocortin Regulation of Inflammation
por: Wang, Wei, et al.
Publicado: (2019)

Leptin Resistance and the Neuro-Adipose Connection
por: Barateiro, Andreia, et al.
Publicado: (2017)

The melanocortin receptors and their accessory proteins
por: Ramachandrappa, Shwetha, et al.
Publicado: (2013)

Development of the Hypothalamic Melanocortin System
por: Coupe, Berengere, et al.
Publicado: (2013)

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling
por: Wang, Xiaozhu, et al.
Publicado: (2022)

Melanocortin-4 Receptor in Spotted Sea Bass, Lateolabrax maculatus: Cloning, Tissue Distribution, Physiology, and Pharmacology
por: Zhang, Kai-Qiang, et al.
Publicado: (2019)

Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin
por: Fruhwürth, Stefanie, et al.
Publicado: (2018)

Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone
por: Martins, Gisele M., et al.
Publicado: (2018)

Melanocortin Systems on Pigment Dispersion in Fish Chromatophores
por: Kobayashi, Yuki, et al.
Publicado: (2012)

Regulation of Melanocortin-4 Receptor Pharmacology by Two Isoforms of Melanocortin Receptor Accessory Protein 2 in Topmouth Culter (Culter alburnus)
por: Tao, Min, et al.
Publicado: (2020)

Case Report: Severe Neonatal Course in Paternally Derived Familial Hypocalciuric Hypercalcemia
por: Höppner, Jakob, et al.
Publicado: (2021)

Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
por: Lin, Yingying, et al.
Publicado: (2023)

Growth Hormone Overexpression Disrupts Reproductive Status Through Actions on Leptin
por: Chen, Ji, et al.
Publicado: (2018)

Melanocortin receptor accessory proteins in adrenal disease and obesity
por: Jackson, David S., et al.
Publicado: (2015)

Effect of Novel Melanocortin Type 2 Receptor Antagonists on the Corticosterone Response to ACTH in the Neonatal Rat Adrenal Gland In Vivo and In Vitro
por: Nensey, Nasha K., et al.
Publicado: (2016)

Leptin and environmental temperature as determinants of bone marrow adiposity in female mice
por: Turner, Russell T., et al.
Publicado: (2022)

Fetal and neonatal thyrotoxicosis
por: Batra, Chandar Mohan
Publicado: (2013)

Plasticity of the Melanocortin System: Determinants and Possible Consequences on Food Intake
por: Nuzzaci, Danaé, et al.
Publicado: (2015)

Dual Topology of the Melanocortin-2 Receptor Accessory Protein Is Stable
por: Maben, Zachary J., et al.
Publicado: (2016)

Management of Amiodarone-Induced Thyrotoxicosis at a Cardiac Transplantation Centre
por: Isaacs, Michelle, et al.
Publicado: (2018)

Central leptin and autonomic regulation: A melanocortin business
por: López, Miguel
Publicado: (2018)

Contributions of maternal and paternal adiposity and smoking to adult offspring adiposity and cardiovascular risk: the Midspan Family Study
por: Han, T S, et al.
Publicado: (2015)

Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats
por: Buonfiglio, Daniella, et al.
Publicado: (2018)

Thyrotoxicosis Mimicking ST Elevation Myocardial Infarction
por: Rymer De Marchena, Ingrid, et al.
Publicado: (2017)

Developmental programming of hypothalamic melanocortin circuits
por: Bouret, Sebastien G.
Publicado: (2022)

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling
por: Müller, Anne, et al.
Publicado: (2016)

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective
por: Heyder, Nicolas, et al.
Publicado: (2019)

Sensing Glucose in the Central Melanocortin Circuits of Rainbow Trout: A Morphological Study
por: Otero-Rodiño, Cristina, et al.
Publicado: (2019)

Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis
por: Tai, Xiaolu, et al.
Publicado: (2022)

Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism
por: Liu, Ruiqi, et al.
Publicado: (2023)

On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin
por: Londraville, Richard Lyle, et al.
Publicado: (2017)

Steroids and Thyrotoxicosis Precipitate Periodic Paralysis
por: Ahamed, Rizwan, et al.
Publicado: (2018)

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion
por: Kuhre, Rune E., et al.
Publicado: (2021)

Advanced Paternal Age and Future Generations
por: Chan, Peter T. K., et al.
Publicado: (2022)

Developmental Exposure to Endocrine Disrupting Chemicals and Type 1 Diabetes Mellitus
por: Howard, Sarah G.
Publicado: (2018)

Melanocortin-4 receptor and leptin as genes for the selection of superior Madrasin cattle
por: Utomo, Budi, et al.
Publicado: (2021)

Diagnosis and Management of Fetal and Neonatal Thyrotoxicosis
por: Bohîlțea, Roxana-Elena, et al.
Publicado: (2022)

Hypothesis and Theory: Evaluating the Co-Evolution of the Melanocortin-2 Receptor and the Accessory Protein MRAP1
por: Dores, Robert M., et al.
Publicado: (2021)

Weight and Glycemic Control Outcomes of Bariatric Surgery and Pharmacotherapy in Patients With Melanocortin-4 Receptor Deficiency
por: Fojas, Esphie Grace Fodra, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r0jsia5qqa0oqjf4slhdj5rpa0