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Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system

BACKGROUND: The genetic code does not fully explain individual variability and inheritance of susceptibility to endocrine conditions, suggesting the contribution of epigenetic factors acting across generations. METHODS: We used a mouse model of developmental thyrotoxicosis (Dio3-/- mouse) to analyze...

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Detalles Bibliográficos
Autores principales:	Martinez, Maria Elena, Wu, Zhaofei, Hernandez, Arturo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407661/ https://www.ncbi.nlm.nih.gov/pubmed/37560296 http://dx.doi.org/10.3389/fendo.2023.1210414

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