Cargando…
Predicting molecular mechanisms of hereditary diseases by using their tissue‐selective manifestation
How do aberrations in widely expressed genes lead to tissue‐selective hereditary diseases? Previous attempts to answer this question were limited to testing a few candidate mechanisms. To answer this question at a larger scale, we developed “Tissue Risk Assessment of Causality by Expression” (TRACE)...
Autores principales: | Simonovsky, Eyal, Sharon, Moran, Ziv, Maya, Mauer, Omry, Hekselman, Idan, Jubran, Juman, Vinogradov, Ekaterina, Argov, Chanan M, Basha, Omer, Kerber, Lior, Yogev, Yuval, Segrè, Ayellet V, Im, Hae Kyung, Birk, Ohad, Rokach, Lior, Yeger‐Lotem, Esti |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407743/ https://www.ncbi.nlm.nih.gov/pubmed/37232043 http://dx.doi.org/10.15252/msb.202211407 |
Ejemplares similares
-
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones
por: Shemesh, Netta, et al.
Publicado: (2021) -
ResponseNet v.3: revealing signaling and regulatory pathways connecting your proteins and genes across human tissues
por: Basha, Omer, et al.
Publicado: (2019) -
Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases
por: Jubran, Juman, et al.
Publicado: (2020) -
The DifferentialNet database of differential protein–protein interactions in human tissues
por: Basha, Omer, et al.
Publicado: (2018) -
Large-scale analysis of human gene expression variability associates highly variable drug targets with lower drug effectiveness and safety
por: Simonovsky, Eyal, et al.
Publicado: (2019)