SREBP2 regulates the endothelial response to cytokines via direct transcriptional activation of KLF6

The transcription factor SREBP2 is the main regulator of cholesterol homeostasis and is central to the mechanism of action of lipid-lowering drugs, such as statins, which are responsible for the largest overall reduction in cardiovascular risk and mortality in humans with atherosclerotic disease. Re...

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Detalles Bibliográficos
Autores principales: Fowler, Joseph Wayne M., Boutagy, Nabil E., Zhang, Rong, Horikami, Daiki, Whalen, Michael B., Romanoski, Casey E., Sessa, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Cholesterol Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407908/
https://www.ncbi.nlm.nih.gov/pubmed/37437844
http://dx.doi.org/10.1016/j.jlr.2023.100411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407908/
https://www.ncbi.nlm.nih.gov/pubmed/37437844
http://dx.doi.org/10.1016/j.jlr.2023.100411

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