Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling

[Image: see text] Thermal proteome profiling (TPP) provides a powerful approach to studying proteome-wide interactions of small therapeutic molecules and their target and off-target proteins, complementing phenotypic-based drug screens. Detecting differences in thermal stability due to target engage...

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Detalles Bibliográficos
Autores principales: George, Amy L., Sidgwick, Frances R., Watt, Jessica E., Martin, Mathew P., Trost, Matthias, Marín-Rubio, José Luis, Dueñas, Maria Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407934/
https://www.ncbi.nlm.nih.gov/pubmed/37439223
http://dx.doi.org/10.1021/acs.jproteome.3c00111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407934/
https://www.ncbi.nlm.nih.gov/pubmed/37439223
http://dx.doi.org/10.1021/acs.jproteome.3c00111

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