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A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche

BACKGROUND: The nutrient-absorbing villi of small intestines are renewed and repaired by intestinal stem cells (ISCs), which reside in a well-organized crypt structure. Genetic studies have shown that Wnt molecules secreted by telocytes, Gli1(+) stromal cells, and epithelial cells are required for I...

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Detalles Bibliográficos
Autores principales: Xiang, Jinnan, Guo, Jigang, Zhang, Shaoyang, Wu, Hongguang, Chen, Ye-Guang, Wang, Junping, Li, Baojie, Liu, Huijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408166/
https://www.ncbi.nlm.nih.gov/pubmed/37553612
http://dx.doi.org/10.1186/s12915-023-01667-2