Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR(WT), EGFR(T790M), and EGFR(L858R))

Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed moderate to good activity against NCI 60 cancer...

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Detalles Bibliográficos
Autores principales: Abo Al-Hamd, Mahmoud G., Tawfik, Haytham O., Abdullah, Omeima, Yamaguchi, Koki, Sugiura, Masaharu, Mehany, Ahmed B. M., El-Hamamsy, Mervat H., El-Moselhy, Tarek F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408569/
https://www.ncbi.nlm.nih.gov/pubmed/37548154
http://dx.doi.org/10.1080/14756366.2023.2241674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408569/
https://www.ncbi.nlm.nih.gov/pubmed/37548154
http://dx.doi.org/10.1080/14756366.2023.2241674

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