Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons

Acid-sensing ion channels (ASICs) are Na(+) channels that are almost ubiquitously expressed in neurons of the brain. Functional ASIC1a is also expressed in glioblastoma stem cells, where it might sense the acidic tumor microenvironment. Prolonged acidosis induces cell death in neurons and reduces tu...

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Detalles Bibliográficos
Autores principales: Pissas, Karolos-Philippos, Schilling, Maria, Tian, Yuemin, Gründer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409673/
https://www.ncbi.nlm.nih.gov/pubmed/37474775
http://dx.doi.org/10.1007/s00424-023-02839-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409673/
https://www.ncbi.nlm.nih.gov/pubmed/37474775
http://dx.doi.org/10.1007/s00424-023-02839-3

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