Cargando…

Genomic dissection of endemic carbapenem resistance reveals metallo-beta-lactamase dissemination through clonal, plasmid and integron transfer

Infections caused by metallo-beta-lactamase-producing organisms (MBLs) are a global health threat. Our understanding of transmission dynamics and how MBLs establish endemicity remains limited. We analysed two decades of bla(IMP-4) evolution in a hospital using sequence data from 270 clinical and env...

Descripción completa

Detalles Bibliográficos
Autores principales:	Macesic, Nenad, Hawkey, Jane, Vezina, Ben, Wisniewski, Jessica A., Cottingham, Hugh, Blakeway, Luke V., Harshegyi, Taylor, Pragastis, Katherine, Badoordeen, Gnei Zweena, Dennison, Amanda, Spelman, Denis W., Jenney, Adam W. J., Peleg, Anton Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409761/ https://www.ncbi.nlm.nih.gov/pubmed/37553339 http://dx.doi.org/10.1038/s41467-023-39915-2

Ejemplares similares

178. Endemic Carbapenem Resistance Driven By Clonal and Horizontal Spread of bla(IMP-4) Across Diverse Enterobacterales: Jumping Genes, Promiscuous Plasmids and Killer Clones
por: Macesic, Nenad, et al.
Publicado: (2021)

Mortality associated with carbapenem-susceptible and Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa bacteremia
por: Persoon, Marjolein C., et al.
Publicado: (2020)

Attributable mortality and excess length of stay associated with third-generation cephalosporin-resistant Enterobacterales bloodstream infections: a prospective cohort study in Suva, Fiji
por: Loftus, Michael J., et al.
Publicado: (2022)

704. Klebsiella pneumoniae Carbapenemase and Verona Integron-Encoded Metallo-β-Lactamase Among Carbapenem-Resistant Enterobacteriaceae in Kentucky
por: Spicer, Kevin, et al.
Publicado: (2018)

Verona Integron–encoded Metallo-β-Lactamase 1 in Enterobacteria, Ontario, Canada
por: Tijet, Nathalie, et al.
Publicado: (2013)

Molecular study of metallo-β-lactamases and integrons in Acinetobacter baumannii isolates from burn patients
por: Nikibakhsh, Mahnaz, et al.
Publicado: (2021)

Detection of Metallo-Beta Lactamases Among Carbapenem-Resistant Pseudomonas aeruginosa
por: Farajzadeh Sheikh, Ahmad, et al.
Publicado: (2014)

ESBL plasmids in Klebsiella pneumoniae: diversity, transmission and contribution to infection burden in the hospital setting
por: Hawkey, Jane, et al.
Publicado: (2022)

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles
por: Makena, Anne, et al.
Publicado: (2016)

Dissemination of Verona Integron-encoded Metallo-β-lactamase among clinical and environmental Enterobacteriaceae isolates in Ontario, Canada
por: Kohler, Philipp, et al.
Publicado: (2020)

Verona Integron-Encoded Metallo-Beta-Lactamase (VIM)–Producing Pseudomonas aeruginosa Outbreak Associated with Acute Care
por: Chan, Allison, et al.
Publicado: (2021)

Phenotypic and genotypic detection of metallo-beta-lactamases in Carbapenem resistant Acinetobacter baumannii
por: Moulana, Zahra, et al.
Publicado: (2020)

Association of the genes encoding Metallo-β-Lactamase with the presence of integrons among multidrug-resistant clinical isolates of Acinetobacter baumannii
por: Amin, Mansour, et al.
Publicado: (2019)

New Delhi Metallo-β-Lactamase-1 in Carbapenem-Resistant Salmonella Strain, China
por: Huang, Jinwei, et al.
Publicado: (2013)

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases
por: Lisa, María-Natalia, et al.
Publicado: (2017)

Notes from the Field: Verona Integron-Encoded Metallo-β-Lactamase–Producing Carbapenem-Resistant Pseudomonas aeruginosa Infections in U.S. Residents Associated with Invasive Medical Procedures in Mexico, 2015–2018
por: Kracalik, Ian, et al.
Publicado: (2019)

Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan
por: Mano, Yoko, et al.
Publicado: (2015)

A Novel Integron Gene Cassette Harboring VIM-38 Metallo-β-lactamase in a Clinical Pseudomonas aeruginosa Isolate
por: Beriş, Fatih Şaban, et al.
Publicado: (2016)

Notes from the Field: Domestically Acquired Verona Integron-Mediated Metallo-β-Lactamase-Producing Enterobacteriaceae — Indiana, 2016–2017
por: Shannon, D.J., et al.
Publicado: (2018)

Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: assessment by a novel clinical tool
por: Persoon, Marjolein C., et al.
Publicado: (2019)

Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor
por: Xiang, Yang, et al.
Publicado: (2020)

Carbapenem-hydrolyzing metallo-beta-lactamase from a nosocomial isolate of Pseudomonas aeruginosa in France.
por: Poirel, L, et al.
Publicado: (2000)

Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy.
por: Rossolini, G M, et al.
Publicado: (2000)

Endemic Carbapenem-resistant Pseudomonas aeruginosa with Acquired Metallo-β-lactamase Determinants in European Hospital
por: Lagatolla, Cristina, et al.
Publicado: (2004)

Carbapenem-Resistant Pseudomonas aeruginosa–Carrying VIM-2 Metallo-β-Lactamase Determinants, Croatia
por: Sardelic, Sanda, et al.
Publicado: (2003)

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota
por: Gudeta, Dereje D., et al.
Publicado: (2016)

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem
por: Tehrani, Kamaleddin H. M. E., et al.
Publicado: (2020)

Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance
por: Wachino, Jun-ichi, et al.
Publicado: (2020)

Further Modification of the Modified Hodge Test for Detecting Metallo-β-Lactamase-Producing Carbapenem-Resistant Enterobacteriaceae
por: Kim, Hyun-Ki, et al.
Publicado: (2015)

Usefulness of phenotypic and genotypic methods for metallo-beta-lactamases detection in carbapenem-resistant Acinetobacter baumannii strains
por: Szejbach, Aleksandra, et al.
Publicado: (2013)

Detection of metallo-beta lactamases and oxacillinase genes in carbapenem-resistant Acinetobacter baumannii strains isolated in Morocco
por: Massik, Abdelhamid, et al.
Publicado: (2021)

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors
por: Reddy, Nakita, et al.
Publicado: (2023)

Epidemiology, antimicrobial resistance and outcomes of Staphylococcus aureus bacteraemia in a tertiary hospital in Fiji: A prospective cohort study
por: Loftus, Michael J., et al.
Publicado: (2022)

Screening for Metallo-Beta-Lactamases Using Non-Carbapenem Agents: Effective Detection of MBL-Producing Enterobacterales and Differentiation of Carbapenem-Resistant Enterobacterales
por: Takei, Kentarou, et al.
Publicado: (2023)

In vivo efficacy of humanized high dose meropenem and comparators against Pseudomonas aeruginosa isolates producing verona integron-encoded metallo-β-lactamase (VIM)
por: Ghazi, Islam M., et al.
Publicado: (2016)

Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase
por: Kim, Youngchang, et al.
Publicado: (2011)

Phenotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii Isolated from Pediatric Patients in Pakistan
por: Anwar, Muneeza, et al.
Publicado: (2016)

New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis, Treatment and Public Health Concern
por: Wei, Wen-Juan, et al.
Publicado: (2015)

Drug Repurposing of the Unithiol: Inhibition of Metallo-β-Lactamases for the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections
por: Grigorenko, Vitaly G., et al.
Publicado: (2022)

Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar
por: Takei, Satomi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5js1imnc7ol76ln0eos4ti3u91