Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology

Familial Alzheimer’s disease (FAD) is a complex neurodegenerative disorder for which there are no therapeutics to date. Several mutations in presenilin 1 (PSEN 1), which is the catalytic component of γ-secretase complex, are causal of FAD. Recently, the p.Ile416Thr (I416T) PSEN 1 mutation has been r...

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Detalles Bibliográficos
Autores principales: Gomez-Sequeda, Nicolas, Mendivil-Perez, Miguel, Jimenez-Del-Rio, Marlene, Lopera, Francisco, Velez-Pardo, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409854/
https://www.ncbi.nlm.nih.gov/pubmed/37553376
http://dx.doi.org/10.1038/s41598-023-39630-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409854/
https://www.ncbi.nlm.nih.gov/pubmed/37553376
http://dx.doi.org/10.1038/s41598-023-39630-4

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