Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity

Memo1 deletion in mice causes premature aging and an unbalanced metabolism partially resembling Fgf23 and Klotho loss-of-function animals. We report a role for Memo’s redox function in renal FGF23-Klotho signaling using mice with postnatally induced Memo deficiency in the whole body (cKO). Memo cKO...

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Detalles Bibliográficos
Autores principales: Bartos, Katalin, Ramakrishnan, Suresh Krishna, Braga-Lagache, Sophie, Hänzi, Barbara, Durussel, Fanny, Prakash Sridharan, Arjun, Zhu, Yao, Sheehan, David, Hynes, Nancy E., Bonny, Olivier, Moor, Matthias B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409928/
https://www.ncbi.nlm.nih.gov/pubmed/36434320
http://dx.doi.org/10.1007/s12079-022-00710-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409928/
https://www.ncbi.nlm.nih.gov/pubmed/36434320
http://dx.doi.org/10.1007/s12079-022-00710-1

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