Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues

Lipid nanoparticles (LNPs) for delivery of mRNA usually contain ionizable lipid/helper lipid/cholesterol/PEG-lipid in molar ratios of 50:10:38.5:1.5, respectively. These LNPs are rapidly cleared from the circulation following intravenous (i.v.) administration, limiting uptake into other tissues. Her...

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Detalles Bibliográficos
Autores principales: Chander, Nisha, Basha, Genc, Yan Cheng, Miffy Hok, Witzigmann, Dominik, Cullis, Pieter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410000/
https://www.ncbi.nlm.nih.gov/pubmed/37564393
http://dx.doi.org/10.1016/j.omtm.2023.06.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410000/
https://www.ncbi.nlm.nih.gov/pubmed/37564393
http://dx.doi.org/10.1016/j.omtm.2023.06.005

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