Accelerated replicative senescence of ataxia‐telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns

The genetic disorder, ataxia‐telangiectasia (A‐T), is caused by loss of the homeostatic protein kinase, ATM, and combines genome instability, tissue degeneration, cancer predisposition, and premature aging. Primary fibroblasts from A‐T patients exhibit premature senescence when grown at ambient oxyg...

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Detalles Bibliográficos
Autores principales: Haj, Majd, Levon, Amit, Frey, Yann, Hourvitz, Noa, Campisi, Judith, Tzfati, Yehuda, Elkon, Ran, Ziv, Yael, Shiloh, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410012/
https://www.ncbi.nlm.nih.gov/pubmed/37254625
http://dx.doi.org/10.1111/acel.13869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410012/
https://www.ncbi.nlm.nih.gov/pubmed/37254625
http://dx.doi.org/10.1111/acel.13869

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