Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal‐dominant Alzheimer's disease

Although pathogenic variants in PSEN1 leading to autosomal‐dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomarker change are observed in ADAD. We hypothesized that this interindividual variability may be associa...

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Detalles Bibliográficos
Autores principales: Schultz, Stephanie A., Shirzadi, Zahra, Schultz, Aaron P., Liu, Lei, Fitzpatrick, Colleen D., McDade, Eric, Barthelemy, Nicolas R., Renton, Alan, Esposito, Bianca, Joseph‐Mathurin, Nelly, Cruchaga, Carlos, Chen, Charles D., Goate, Alison, Allegri, Ricardo Francisco, Benzinger, Tammie L. S., Berman, Sarah, Chui, Helena C., Fagan, Anne M., Farlow, Martin R., Fox, Nick C., Gordon, Brian A., Day, Gregory S., Graff‐Radford, Neill R., Hassenstab, Jason J., Hanseeuw, Bernard J., Hofmann, Anna, Jack, Clifford R., Jucker, Mathias, Karch, Celeste M., Koeppe, Robert A., Lee, Jae‐Hong, Levey, Allan I., Levin, Johannes, Martins, Ralph N., Mori, Hiroshi, Morris, John C., Noble, James, Perrin, Richard J., Rosa‐Neto, Pedro, Salloway, Stephen P., Sanchez‐Valle, Raquel, Schofield, Peter R., Xiong, Chengjie, Johnson, Keith A., Bateman, Randall J., Sperling, Reisa A., Chhatwal, Jasmeer P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410059/
https://www.ncbi.nlm.nih.gov/pubmed/37291760
http://dx.doi.org/10.1111/acel.13871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410059/
https://www.ncbi.nlm.nih.gov/pubmed/37291760
http://dx.doi.org/10.1111/acel.13871

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