Impact of Propeptide Cleavage on the Stability and Activity of a Streptococcal Immunomodulatory C5a Peptidase for Biopharmaceutical Development

[Image: see text] Posttranslational modifications of proteins can impact their therapeutic efficacy, stability, and potential for pharmaceutical development. The Group AStreptococcus pyogenesC5a peptidase (ScpA) is a multi-domain protein composed of an N-terminal signal peptide, a catalytic domain (...

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Detalles Bibliográficos
Autores principales: Gedi, Vinayakumar, Duarte, Francisco, Patel, Pratikkumar, Bhattacharjee, Promita, Tecza, Malgorzata, McGourty, Kieran, Hudson, Sarah P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410607/
https://www.ncbi.nlm.nih.gov/pubmed/37406301
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410607/
https://www.ncbi.nlm.nih.gov/pubmed/37406301
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00207

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